Human CellExp™ Siglec-2 / CD22 isoform beta, Human Recombinant

Human CellExp™ Siglec-2 / CD22 isoform beta, Human Recombinant is available at Gentaur for Next week delivery.

Mediates B-cell B-cell interactions and involved in the localization of B-cells in lymphoid tissues

Biomolecule/Target: CD22

Alternates names: CD22, SIGLEC2, BL-CAM, Leu-14

Synonyms: CD22, SIGLEC2, BL-CAM, Leu-14

Background Information: B-cell receptor CD22 is also known as Sialic acid-binding Ig-like lectin 2 (Siglec-2), B-lymphocyte cell adhesion molecule (BL-CAM), T-cell surface antigen Leu-14, which belongs to the immunoglobulin superfamily and SIGLEC (sialic acid binding Ig-like lectin) family. CD22 mediates B-cell B-cell interactions, and may be involved in the localization of B-cells in lymphoid tissues. Siglec-2 / CD22 binds sialylated glycoproteins, one of which is CD45. Siglec2 / CD22 plays a role in positive regulation through interaction with Src family tyrosine kinases and may also act as an inhibitory receptor by recruiting cytoplasmic phosphatases via their SH2 domains that block signal transduction through dephosphorylation of signaling molecules.

Reconstitution Instructions: Reconstitute in sterile deionized water to a concentration up to 0.2 mg/ml.

NCBI Gene Symbol: CD22

Gene ID: 933

NCBI Accession: P20273