Human CellExp™ sCD14, Human Recombinant

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SKU:
7122-50
£135.37
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Description

Human CellExp™ sCD14, Human Recombinant is available at Gentaur for Next week delivery.

A surface glycoprotein involved in signaling in response to bacterial lipopolysaccharide (LPS) binding

Biomolecule/Target: sCD14

Alternates names: soluble CD14, Cluster of differentiation 14, Myeloid cell-specific leucine-rich glycoprotein, Monocyte differentiation antigen CD14

Synonyms: soluble CD14, Cluster of differentiation 14, Myeloid cell-specific leucine-rich glycoprotein, Monocyte differentiation antigen CD14

Background Information: CD14 is a cell surface anchored glycoprotein that is expressed predominantly by monocytes and tissue macrophages. CD14 associates with MD-2 (LY-96) and TLR4 to form a receptor complex, which signals specifically in response to bacterial lipopolysaccharide (LPS) binding. The CD14/MD-2/TLR4 receptor complex signals via MyD88, TIRAP, and TRAF6, and ultimately activates NF-kappa-β. CD14 also exists in a soluble form, designated as sCD14, which is capable of specifically binding LPS in the extracellular space. Recombinant sCD14 is a 331 amino acid glycoprotein comprising the extracellular portion of the CD14 receptor.

Reconstitution Instructions: Centrifuge the vial prior to opening. Reconstitute in water to a concentration of 0.1-1.0 mg/ml. Do not vortex. This solution can be stored at 2-8°C for up to 1 week. For extended storage, it is recommended to further dilute in a buffer containing a carrier protein (example 0.1% BSA) and store in working aliquots at -20°C to -80°C.

NCBI Gene Symbol: CD14

Gene ID: 929

NCBI Accession: P08571

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Additional Information

Size:
50 μg
Country of Manufacturing Origin:
USA
Country of Animal Origin:
USA
Gene Source:
Human
Recombinant:
Yes
Source:
HEK 293 cells
Purity by SDS-PAGE:
≥95%
Assay:
SDS-PAGE
Purity:
N/A
Assay 2:
HPLC
Endotoxin Level:
< 0.1 ng/μg of protein (<1EU/μg).
Activity (Specifications/test method):
Determined by the dose dependent activation of NF-kappaB in a RAW264 cell line based
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