BioVision Proteins
Human CellExp™ PLAU / uPA (Activated), Human Recombinant
- SKU:
- P1549-10
Description
Human CellExp™ PLAU / uPA (Activated), Human Recombinant is available at Gentaur for Next week delivery.
A potent marker of invasion and metastasis in a variety of human cancers
Biomolecule/Target:
Alternates names: Urokinase, PLAU, ATF, UPA, URK, u-PA, BDPLT5, QPD
Synonyms: Urokinase, PLAU, ATF, UPA, URK, u-PA, BDPLT5, QPD
Background Information: Urokinase-type plasminogen activator is also known as PLAU and UPA, a serine protease with an extremely limited substrate specificity, cleaving the sequence Cys – Pro – Gly - Arg560 - Val561 – Val – Gly – Gly – Cys in plasminogen to form plasmin. uPA is a potent marker of invasion and metastasis in a variety of human cancers associated with breast, stomach, colon, bladder, ovary, brain and endometrium.uPA and its receptor (uPAR) have been implicated in a broad spectrum of pathophysiological processes, including fibrinolysis, proteolysis, inflammation, atherogenesis and plaque destabilization, all of which are involved in the pathogenesis of MI (myocardial infarction).
Reconstitution Instructions: Centrifuge the vial prior to opening. Reconstitute in deionized water. Do not vortex. For extended storage, it is recommended to store at -70°C
NCBI Gene Symbol: PLAU
Gene ID: 5328
NCBI Accession: P00749-1
Additional Information
Size: |
10 µg |
Adwords: |
FAUX |
Country of Manufacturing Origin: |
USA |
Country of Animal Origin: |
USA |
Gene Source: |
Human |
Recombinant: |
VRAI |
Source: |
HEK 293 cells |
Purity by SDS-PAGE: |
>90% |
Endotoxin Level: |
Less than 1.0 EU per μg by the LAL method. |
Activity (Specifications/test method): |
Measured by it's ability to cleave a peptide substrate, N-carbobenzyloxy-Gly-Gly-Arg-7-amido-4-methylcoumarin (Z-GGR-AMC). The specific activity is >2,000 pmol/min/µg, as measured under the described conditions. |
Molecular Weight: |
This protein carries a polyhistidine tag at the C-terminus. The active form of Human PLAU is a disulfide-linked heterodimer composed of long chain A (Ser 21 - Phe 177) and chain B (Ile 179 - Leu 431) with calculated MW of 17.8 kDa and 29.2 kDa. The l |
Storage Temperature: |
-20ºC |
Shelf Life: |
12 months |
Appearance: |
Lyophilized powder |
Handling: |
Centrifuge the vial prior to opening. |