Human CellExp™ PLAU / uPA (Activated), Human Recombinant

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SKU:
P1549-10
€185
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Description

Human CellExp™ PLAU / uPA (Activated), Human Recombinant is available at Gentaur for Next week delivery.

A potent marker of invasion and metastasis in a variety of human cancers

Biomolecule/Target:

Alternates names: Urokinase, PLAU, ATF, UPA, URK, u-PA, BDPLT5, QPD

Synonyms: Urokinase, PLAU, ATF, UPA, URK, u-PA, BDPLT5, QPD

Background Information: Urokinase-type plasminogen activator is also known as PLAU and UPA, a serine protease with an extremely limited substrate specificity, cleaving the sequence Cys – Pro – Gly - Arg560 - Val561 – Val – Gly – Gly – Cys in plasminogen to form plasmin. uPA is a potent marker of invasion and metastasis in a variety of human cancers associated with breast, stomach, colon, bladder, ovary, brain and endometrium.uPA and its receptor (uPAR) have been implicated in a broad spectrum of pathophysiological processes, including fibrinolysis, proteolysis, inflammation, atherogenesis and plaque destabilization, all of which are involved in the pathogenesis of MI (myocardial infarction).

Reconstitution Instructions: Centrifuge the vial prior to opening. Reconstitute in deionized water. Do not vortex. For extended storage, it is recommended to store at -70°C

NCBI Gene Symbol: PLAU

Gene ID: 5328

NCBI Accession: P00749-1

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Additional Information

Size:
10 µg
Adwords:
FAUX
Country of Manufacturing Origin:
USA
Country of Animal Origin:
USA
Gene Source:
Human
Recombinant:
VRAI
Source:
HEK 293 cells
Purity by SDS-PAGE:
>90%
Endotoxin Level:
Less than 1.0 EU per μg by the LAL method.
Activity (Specifications/test method):
Measured by it's ability to cleave a peptide substrate, N-carbobenzyloxy-Gly-Gly-Arg-7-amido-4-methylcoumarin (Z-GGR-AMC). The specific activity is >2,000 pmol/min/µg, as measured under the described conditions.
Molecular Weight:
This protein carries a polyhistidine tag at the C-terminus. The active form of Human PLAU is a disulfide-linked heterodimer composed of long chain A (Ser 21 - Phe 177) and chain B (Ile 179 - Leu 431) with calculated MW of 17.8 kDa and 29.2 kDa. The l
Storage Temperature:
-20ºC
Shelf Life:
12 months
Appearance:
Lyophilized powder
Handling:
Centrifuge the vial prior to opening.
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