Human CellExp™ M-CSF, Human Recombinant

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SKU:
6455-50
£135.37
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Description

Human CellExp™ M-CSF, Human Recombinant is available at Gentaur for Next week delivery.

A hematopoietic growth factor

Biomolecule/Target: M-CSF

Alternates names: Macrophage Colony Stimulating Factor, CSF-1, Lanimostim, MCSF, MGC31930, M-CSF.

Synonyms: Human Cellexp Human Recombinant M-CSF

Background Information: Granulocyte/Macrophage Colony-Stimulating Factors (M-CSF) are cytokines that act in hematopoiesis by controlling the production, differentiation, and function of granulocytes and monocytes-macrophages. M-CSF plays an essential role in the regulation of survival, proliferation and differentiation of hematopoietic precursor cells, especially mononuclear phagocytes, such as macrophages and monocytes. It also plays an important role in innate immunity and in inflammatory processes by promoting the release of proinflammatory chemokines. M-CSF is also required for normal bone development and male/female fertility.

Reconstitution Instructions: Centrifuge the vial prior to opening. Reconstitute in sterile PBS (pH 7.4). Do not vortex.

NCBI Gene Symbol: CSF1

Gene ID: 1435

NCBI Accession: P09603

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Additional Information

Size:
50 μg
Country of Manufacturing Origin:
USA
Country of Animal Origin:
USA
Gene Source:
Human
Recombinant:
Yes
Source:
Human 293 cell expressed
Purity by SDS-PAGE:
≥95%
Assay:
SDS-PAGE
Purity:
N/A
Assay 2:
N/A
Endotoxin Level:
< 1.0 EU per 1 μg of protein
Activity (Specifications/test method):
N/A
Biological activity:
The EC50 is typically 0.5 to 4 ng/mL for this protein with specific activity determined by the dose dependent stimulation of the proliferation of murine M-NFS-60 cells (Mouse Myeloid Leukemia indicator cell line)
Results:
0.5 to 4 ng/ml
Molecular Weight:
This protein has 223 amino acids (Glu 33 - Arg 255) with a 6x-His tag at C-terminus, and a calculated MW of 26 kDa. The protein migrates to 35-45 kDa under reducing and non-reducing conditions (SDS-PAGE) due to glycosylation
Storage Temperature:
-20°C
Shelf Life:
12 months
Concentration:
N/A
Appearance:
Lyophilized
Handling:
Centrifuge the vial prior to opening.
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