Human CellExp™ LOXL2, human recombinant

Human CellExp™ LOXL2, human recombinant is available at Gentaur for Next week delivery.

Mediates the post-translational oxidative deamination of lysine residues on target proteins.

Biomolecule/Target: LOXL2

Alternates names: Lysyl oxidase homolog 2, LOXL2

Synonyms: Lysyl oxidase homolog 2, LOXL2

Background Information: Lysyl oxidase homolog 2 also known as LOXL2, Lysyl oxidase-like protein 2, which is expressed in many tissues, highest expression in reproductive tissues, placenta, uterus and prostate, Up-regulated in a number of cancers cells and tissues. LOXL2 mediates the post-translational oxidative deamination of lysine residues on target proteins leading to the formation of deaminated lysine (allysine). When secreted in extracellular matrix, promotes cross-linking of extracellular matrix proteins by mediating oxidative deamination of peptidyl lysine residues in precursors to fibrous collagen and elastin. LOXL2 acts as a regulator of sprouting angiogenesis, probably via collagen IV scaffolding. When nuclear, acts as a transcription corepressor and specifically mediates deamination of trimethylated 'Lys-4' of histone H3 (H3K4me3), a specific tag for epigenetic transcriptional activation. LOXL2 acts as a regulator of chondrocyte differentiation, probably by regulating expression of factors that control chondrocyte differentiation.

Reconstitution Instructions: Reconstitute in sterile deionized water to a concentration of 50 μg/ml.

NCBI Gene Symbol: LOXL2

Gene ID: 4017

NCBI Accession: Q9Y4K0