Human CellExp™ LILRB4 / CD85k / ILT3, Cynomolgus Recombinant

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SKU:
P1187-50
€185
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Description

Human CellExp™ LILRB4 / CD85k / ILT3, Cynomolgus Recombinant is available at Gentaur for Next week delivery.

Receptor for class I MHC antigens

Biomolecule/Target: LILRB4

Alternates names: LILRB4, ILT3, LIR5, CD85K, HM18

Synonyms: LILRB4, ILT3, LIR5, CD85K, HM18

Background Information: Leukocyte immunoglobulin-like receptor subfamily B member 4 (LILRB4) is also known as CD85 antigen-like family member K (CD85K), Immunoglobulin-like transcript 3 (ILT-3), Leukocyte immunoglobulin-like receptor 5 (LIR-5), Monocyte inhibitory receptor HM18, which belongs to the leukocyte immunoglobulin-like receptor (LIR) family. LILRB4 / CD85K contains 2 Ig-like C2-type (immunoglobulin-like) domains. CD85K is detected in monocytes, macrophages, dendritic cells, lung, natural killer cells and B-cells. LILRB4 / CD85K is receptor for class I MHC antigens. CD85K recognizes a broad spectrum of HLA-A, HLA-B, HLA-C and HLA-G alleles, involved in the down-regulation of the immune response and the development of tolerance. LILRB4 interferes with TNFRSF5-signaling and NF-kappa-B up-regulation and inhibits receptor-mediated phosphorylation of cellular proteins and mobilization of intracellular calcium ions.

Reconstitution Instructions: Reconstitute in sterile deionized water to the desired protein concentration.

NCBI Gene Symbol: LILRB4

Gene ID: 107128256

NCBI Accession: XP_015297198.1

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Additional Information

Size:
50 μg
Country of Manufacturing Origin:
USA
Country of Animal Origin:
USA
Gene Source:
Human
Recombinant:
Yes
Source:
HEK293 cells
Purity by SDS-PAGE:
> 85%
Assay:
SDS-PAGE
Purity:
N/A
Assay 2:
N/A
Endotoxin Level:
< 1.0 EU per/μg
Activity (Specifications/test method):
Measured by its binding ability in a functional ELISA.
Biological activity:
Immobilized Human ANGPTL7, His Tag at 5 μg/mL (100 μL/well) can bind Cynomolgus LILRB4, Fc Tag with a linear range of 10-156 ng/mL.
Results:
N/A
Molecular Weight:
52.7 kDa
Storage Temperature:
-20°C
Shelf Life:
12 months
Concentration:
N/A
Appearance:
Lyophilized
Handling:
Centrifuge the vial prior to opening.
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