BioVision Proteins
Human CellExp™ LILRB4 / CD85k / ILT3, Cynomolgus Recombinant
- SKU:
- P1187-50
Description
Human CellExp™ LILRB4 / CD85k / ILT3, Cynomolgus Recombinant is available at Gentaur for Next week delivery.
Receptor for class I MHC antigens
Biomolecule/Target: LILRB4
Alternates names: LILRB4, ILT3, LIR5, CD85K, HM18
Synonyms: LILRB4, ILT3, LIR5, CD85K, HM18
Background Information: Leukocyte immunoglobulin-like receptor subfamily B member 4 (LILRB4) is also known as CD85 antigen-like family member K (CD85K), Immunoglobulin-like transcript 3 (ILT-3), Leukocyte immunoglobulin-like receptor 5 (LIR-5), Monocyte inhibitory receptor HM18, which belongs to the leukocyte immunoglobulin-like receptor (LIR) family. LILRB4 / CD85K contains 2 Ig-like C2-type (immunoglobulin-like) domains. CD85K is detected in monocytes, macrophages, dendritic cells, lung, natural killer cells and B-cells. LILRB4 / CD85K is receptor for class I MHC antigens. CD85K recognizes a broad spectrum of HLA-A, HLA-B, HLA-C and HLA-G alleles, involved in the down-regulation of the immune response and the development of tolerance. LILRB4 interferes with TNFRSF5-signaling and NF-kappa-B up-regulation and inhibits receptor-mediated phosphorylation of cellular proteins and mobilization of intracellular calcium ions.
Reconstitution Instructions: Reconstitute in sterile deionized water to the desired protein concentration.
NCBI Gene Symbol: LILRB4
Gene ID: 107128256
NCBI Accession: XP_015297198.1
Additional Information
Size: |
50 μg |
Country of Manufacturing Origin: |
USA |
Country of Animal Origin: |
USA |
Gene Source: |
Human |
Recombinant: |
Yes |
Source: |
HEK293 cells |
Purity by SDS-PAGE: |
> 85% |
Assay: |
SDS-PAGE |
Purity: |
N/A |
Assay 2: |
N/A |
Endotoxin Level: |
< 1.0 EU per/μg |
Activity (Specifications/test method): |
Measured by its binding ability in a functional ELISA. |
Biological activity: |
Immobilized Human ANGPTL7, His Tag at 5 μg/mL (100 μL/well) can bind Cynomolgus LILRB4, Fc Tag with a linear range of 10-156 ng/mL. |
Results: |
N/A |
Molecular Weight: |
52.7 kDa |
Storage Temperature: |
-20°C |
Shelf Life: |
12 months |
Concentration: |
N/A |
Appearance: |
Lyophilized |
Handling: |
Centrifuge the vial prior to opening. |