Human CellExp™ Insulin R / CD220, Human Recombinant

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SKU:
P1377-50
£135.37
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Description

Human CellExp™ Insulin R / CD220, Human Recombinant is available at Gentaur for Next week delivery.

Receptor tyrosine kinase which mediates the pleiotropic actions of insulin.

Biomolecule/Target: Insulin R / CD220

Alternates names: INSR, Insulin receptor, IR, CD220

Synonyms: INSR, Insulin receptor, IR, CD220

Background Information: Insulin receptor (INSR) is also known as CD antigen CD220, which can be cleaved into the following 2 chains: Insulin receptor subunit alpha and Insulin receptor subunit beta. INSR is a tetramer of 2 alpha and 2 beta chains linked by disulfide bonds. The alpha chains carry the insulin-binding regions, while the beta chains carry the kinase domain. Forms a hybrid receptor with IGF1R, the hybrid is a tetramer consisting of 1 alpha chain and 1 beta chain of INSR and 1 alpha chain and 1 beta chain of IGF1R. In addition to binding insulin, the insulin receptor can bind insulin-like growth factors (IGFI and IGFII). Isoform Short of INSR has a higher affinity for IGFII binding. When present in a hybrid receptor with IGF1R, INSR binds IGF1.

Reconstitution Instructions: Centrifuge the vial prior to opening. Reconstitute in sterile deionized water, pH 7.4 to a concentration of 50 µg/ml. Do not vortex. It is recommended to store at -20°C.

NCBI Gene Symbol: IRS1

Gene ID: 3667

NCBI Accession: P06213-2

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Additional Information

Size:
50 µg
Country of Manufacturing Origin:
USA
Country of Animal Origin:
USA
Gene Source:
Human
Recombinant:
VRAI
Source:
HEK 293 cells
Purity by SDS-PAGE:
>90% as determined by SDS-PAGE
Endotoxin Level:
Less than 1.0 EU per μg by the LAL method.
Activity (Specifications/test method):
Immobilized Human Insulin R (28-944), His Tag at 5 μg/mL (100 μL/well) can bind Human IGF-II, Fc Tag with a linear range of 0.078-1.25 μg/mL
Molecular Weight:
106.5 kDa (His 28 - Lys 944)
Storage Temperature:
-20°C
Shelf Life:
12 months
Appearance:
Lyophilized powder
Handling:
Centrifuge the vial prior to opening.
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