Human CellExp™ Insulin R / CD220, Human Recombinant

Human CellExp™ Insulin R / CD220, Human Recombinant is available at Gentaur for Next week delivery.

Receptor tyrosine kinase which mediates the pleiotropic actions of insulin.

Biomolecule/Target: Insulin R / CD220

Alternates names: INSR, Insulin receptor, IR, CD220

Synonyms: INSR, Insulin receptor, IR, CD220

Background Information: Insulin receptor (INSR) is also known as CD antigen CD220, which can be cleaved into the following 2 chains: Insulin receptor subunit alpha and Insulin receptor subunit beta. INSR is a tetramer of 2 alpha and 2 beta chains linked by disulfide bonds. The alpha chains carry the insulin-binding regions, while the beta chains carry the kinase domain. Forms a hybrid receptor with IGF1R, the hybrid is a tetramer consisting of 1 alpha chain and 1 beta chain of INSR and 1 alpha chain and 1 beta chain of IGF1R. In addition to binding insulin, the insulin receptor can bind insulin-like growth factors (IGFI and IGFII). Isoform Short of INSR has a higher affinity for IGFII binding. When present in a hybrid receptor with IGF1R, INSR binds IGF1.

Reconstitution Instructions: Centrifuge the vial prior to opening. Reconstitute in sterile deionized water, pH 7.4 to a concentration of 50 µg/ml. Do not vortex. It is recommended to store at -20°C.

NCBI Gene Symbol: IRS1

Gene ID: 3667

NCBI Accession: P06213-2