Human CellExp™ IL13RA1/CD213A1, human recombinant

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SKU:
7433-50
€185
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Description

Human CellExp™ IL13RA1/CD213A1, human recombinant is available at Gentaur for Next week delivery.

Shown to bind tyrosine kinase TYK2 to mediate various signaling processes.

Biomolecule/Target: IL13RA1/CD213A1

Alternates names: IL13RA1, CD213A1, IL-13Ra, NR4, RP13-128O4.2, IL13Rα1

Synonyms: IL13RA1, CD213A1, IL-13Ra, NR4, RP13-128O4.2, IL13Rα1

Background Information: Interleukin 13 receptor, alpha 1, also known as IL13RA1, NR4 and CD213A1 (cluster of differentiation 213A1), The IL13 Rα1 cDNA encodes a 427 amino acid (aa) residue precursor protein with a putative 21 aa residue signal peptide, a 324 aa residue extracellular domain, a 23 aa residue transmembrane region and a 59 aa residue cytoplasmic tail. Human and mouseIL13Rα1 share 76% aa sequence identity. IL13RA1 is a subunit of the interleukin 13 receptor. This subunit forms a receptor complex with IL4 receptor alpha, a subunit shared by IL13 and IL4 receptors. This subunit serves as a primary IL13-binding subunit of the IL13 receptor, and may also be a component of IL4 receptors. This protein has been shown to bind tyrosine kinase TYK2, and thus may mediate the signaling processes that lead to the activation of JAK1, STAT3 and STAT6 induced by IL13 and IL4.

Reconstitution Instructions: Centrifuge the vial prior to opening. Reconstitute in sterile PBS, pH 7.4 to a concentration of 50 µg/ml. Do not vortex. This solution can be stored at 2-8°C for up to 1 month. For extended storage, it is recommended to store at -20°C.

NCBI Gene Symbol: IL13RA1

Gene ID: 3597

NCBI Accession: P78552

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Additional Information

Size:
50 μg
Country of Manufacturing Origin:
USA
Country of Animal Origin:
USA
Gene Source:
Human
Recombinant:
Yes
Source:
HEK293 cells
Purity by SDS-PAGE:
≥98%
Assay:
SDS-PAGE
Purity:
N/A
Assay 2:
N/A
Endotoxin Level:
<1 EU/μg by LAL method
Activity (Specifications/test method):
N/A
Biological activity:
Measured by its binding ability in a functional ELISA. Immobilized rhIL13Ra1 at 2 μg/mL (100 μL/well) can bind rhIL13 with a linear range of 0.1-10 ng/mL.
Results:
Measured by its binding ability in a functional ELISA. Immobilized rhIL13Ra1 at 2 μg/mL (100 μL/well) can bind rhIL13 with a linear range of 0.1-10 ng/mL.
Molecular Weight:
This protein is fused with a 6×his tag at the C-terminus and the protein has a calculated MW of 38 kDa. DTT-reduced protein migrates as 55-65 kDa in SDS-PAGE due to glycosylation.
Storage Temperature:
-20°C
Shelf Life:
12 months
Concentration:
N/A
Appearance:
Lyophilized
Handling:
Centrifuge the vial prior to opening.
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