Human CellExp™ IL-5, Human Recombinant

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SKU:
P1486-50
€185
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Description

Human CellExp™ IL-5, Human Recombinant is available at Gentaur for Next week delivery.

Factor that induces terminal differentiation of late-developing B-cells to immunoglobulin secreting cells.

Biomolecule/Target:

Alternates names: Interleukin-5, IL-5, B-cell differentiation factor I, Eosinophil differentiation factor, T-cell replacing factor, TRF

Synonyms: Interleukin-5, IL-5, B-cell differentiation factor I, Eosinophil differentiation factor, T-cell replacing factor, TRF

Background Information: Interleukin-5 (IL-5) is identified by its ability to support the growth and terminal differentiation of mouse B cells to immunoglobulin secreting cells. IL-5 also exerts pleiotropic activities on various target cells including eosinophils and basophils via receptors of IL-5-specific α and common β-subunit. IL-5’s stimulation of eosinophil has been implicated in the pathogenesis of allergic inflammatory diseases, such as asthma. Targeting the interleukin-5 pathway offers benefit to patients with severe asthma. Mepolizumab is an anti-interleukin-5 (IL-5) humanized monoclonal antibody that has been approved as an add-on biological treatment for severe eosinophilic asthma, by both the US Food and Drug Administration (FDA) and the European Medicines Agency (EMA).

Reconstitution Instructions: Centrifuge the vial prior to opening. Reconstitute in sterile PBS (pH 7.4). Do not vortex.

NCBI Gene Symbol: IL5

Gene ID: 3567

NCBI Accession: P05113

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Additional Information

Size:
50 µg
Adwords:
False
Country of Manufacturing Origin:
USA
Country of Animal Origin:
USA
Gene Source:
Human
Recombinant:
False
Source:
HEK 293 cells
Purity by SDS-PAGE:
>95%
Activity (Specifications/test method):
ED50 is typically < 1 ng/mL. The specific activity was determined by the dose dependent stimulation of the proliferation of Human TF-1 cells using BioVision’s Quick Cell Proliferation colorimetric Assay Kit Plus (Cat. No. K302).
Molecular Weight:
14 kDa with a 6×His tag at the N-terminus
Storage Temperature:
-20ºC
Shelf Life:
12 months
Appearance:
Lyophilized powder
Handling:
Centrifuge the vial prior to opening.
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