Human CellExp™ IL-22, human recombinant

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SKU:
7272-10
£135.37
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Description

Human CellExp™ IL-22, human recombinant is available at Gentaur for Next week delivery.

Initiates innate immune responses against bacterial pathogens

Biomolecule/Target: IL-22

Alternates names: IL-22, IL-TIF, ZCYTO18

Synonyms: IL-22, IL-TIF, ZCYTO18

Background Information: Interleukin-22 (IL22) is also known as cytokine Zcyto18, IL-10-related T-cell-derived-inducible factor (IL-TIF), which is belongs to the IL-10 family or IL-10 superfamily (including IL-19, IL-20, IL-24, and IL-26), a class of potent mediators of cellular inflammatory responses. IL-22 is produced by activated DC and T cells and initiates innate immune responses against bacterial pathogens especially in epithelial cells such as respiratory and gut epithelial cells. IL-22 biological activity is initiated by binding to a cell-surface complex composed of IL-22R1 and IL-10R2 receptor chains and further regulated by interactions with a soluble binding protein IL-22BP. IL-22 also promotes hepatocyte survival in the liver and epithelial cells in the lung and gut similar to IL-10.

Reconstitution Instructions: Centrifuge the vial prior to opening. Reconstitute in sterile deionized water to a concentration of 100 µg/ml. Do not vortex. This solution can be stored at 2-8°C for up to 1 month. For extended storage, it is recommended to store at -20°C.

NCBI Gene Symbol: IL-22

Gene ID: 50616

NCBI Accession: Q9GZX6

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Additional Information

Size:
10 μg
Country of Manufacturing Origin:
USA
Country of Animal Origin:
USA
Gene Source:
Human
Recombinant:
Yes
Source:
HEK 293 cells
Purity by SDS-PAGE:
≥95%
Assay:
SDS-PAGE
Purity:
N/A
Assay 2:
N/A
Endotoxin Level:
< 0.1 ng/μg of protein (<1EU/μg) by LAL method
Activity (Specifications/test method):
Measured by its ability to induce IL-10 secretion in COLO 205 (human colon carcinoma cells). The ED50 for this effect is 0.5 - 1.0 ng/ml
Biological activity:
Measured by its ability to activate STAT following receptor ligand interaction.
Results:
N/A
Molecular Weight:
Calculated MW of 17.2 kDa with no tag. The predicted N-terminus is Ala 34.
Storage Temperature:
-20°C
Shelf Life:
12 months
Concentration:
N/A
Appearance:
Lyophilized powder
Handling:
Centrifuge the vial prior to opening.
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