Human CellExp™ ICOS / CD278, Mouse Recombinant

Human CellExp™ ICOS / CD278, Mouse Recombinant is available at Gentaur for Next week delivery.

Inducible T-cell costimulator

Biomolecule/Target:

Alternates names: ICOS, CD278, AILIM, Inducible T-cell costimulator

Synonyms: ICOS, CD278, AILIM, Inducible T-cell costimulator

Background Information: Inducible T-cell costimulator (ICOS) is also known as Activation-inducible lymphocyte immunomediatory molecule (AILIM), CD278, which belongs to the CD28 family of immune costimulatory receptors consisting of CD28, CTLA-4 and PD-1. ICOS enhances all basic T-cell responses to a foreign antigen, namely proliferation, secretion of lymphokines, up-regulation of molecules that mediate cell-cell interaction, and effective help for antibody secretion by B-cells. CD278 / ICOS prevents the apoptosis of pre-activated T-cells and also plays a critical role in CD40-mediated class switching of immunoglobin isotypes.

Reconstitution Instructions: Reconstitute in sterile deionized water to the desired protein concentration.

NCBI Gene Symbol: Icos

Gene ID: 54167

NCBI Accession: Q9WVS0-1