Human CellExp™ ICOS / CD278, Fc Tag, Human recombinant

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SKU:
P1378-50
€185
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Description

Human CellExp™ ICOS / CD278, Fc Tag, Human recombinant is available at Gentaur for Next week delivery.

Inducible T-cell costimulator

Biomolecule/Target: ICOS / CD278

Alternates names: ICOS, CD278, AILIM, Inducible T-cell costimulator

Synonyms: ICOS, CD278, AILIM, Inducible T-cell costimulator

Background Information: Inducible T-cell costimulator (ICOS) is also known as Activation-inducible lymphocyte immunomediatory molecule (AILIM), CD278, which belongs to the CD28 family of immune costimulatory receptors consisting of CD28, CTLA-4 and PD-1. ICOS enhances all basic T-cell responses to a foreign antigen, namely proliferation, secretion of lymphokines, up-regulation of molecules that mediate cell-cell interaction, and effective help for antibody secretion by B-cells. CD278 / ICOS prevents the apoptosis of pre-activated T-cells and also plays a critical role in CD40-mediated class switching of immunoglobin isotypes.

Reconstitution Instructions: Centrifuge the vial prior to opening. Reconstitute in sterile deionized water, pH 7.4 to a concentration of 50 µg/ml. Do not vortex. It is recommended to store at -20°C.

NCBI Gene Symbol: CD278

Gene ID: 29851

NCBI Accession: NP_036224

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Additional Information

Size:
50 µg
Country of Manufacturing Origin:
USA
Country of Animal Origin:
USA
Gene Source:
Human
Recombinant:
VRAI
Source:
HEK 293 cells
Purity by SDS-PAGE:
>95% as determined by SDS-PAGE.
Endotoxin Level:
Less than 1.0 EU per μg by the LAL method.
Activity (Specifications/test method):
Immobilized Human B7-H2, His Tag at 1 μg/mL (100 μL/well) can bind Human ICOS, Fc Tag with a linear range of 0.4-6 ng/mL
Molecular Weight:
This protein carries a human IgG1 Fc tag at the C-terminus. The protein has a calculated MW of 40.2 kDa. The protein migrates as 46-55 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
Storage Temperature:
-20°C
Shelf Life:
12 months
Appearance:
Sterile Filtered colorless solution
Handling:
Centrifuge the vial prior to opening.
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