Human CellExp™ Hemopexin, Human Recombinant

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SKU:
P1210-50
£135.37
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Description

Human CellExp™ Hemopexin, Human Recombinant is available at Gentaur for Next week delivery.

A blood transport protein that acts as an extracellular antioxidant against hemoglobin-mediated damage in inflammation.

Biomolecule/Target: Hemopexin

Alternates names: Beta-1B-glycoprotein, HPX, Hpxn

Synonyms: Beta-1B-glycoprotein, HPX, Hpxn

Background Information: Hemopexin (HPX) is plasma glycoprotein belongs to the family of the acute-phase proteins whose synthesis is induced after an inflammatory event. Hemopexin with two four-bladed beta -propeller folds has been found in other proteins including collagenases and provides sites for protein-protein interactions. The liver is the major synthesizing organ. Hemopexin participates in maintaining and recycling the iron pool by utilizing its high binding affinity toward heme composed of protoporphyrin IX and iron. It also functions in preventing oxidation caused by heme after hemolysis. Hydrophobic heme molecules can intercalate into lipid membranes and participate in the oxidation of lipid membrane components through the Fenton reaction resulting in lipid peroxidation. Hemopexin undergoes a conformational change upon the binding of heme. The conformational change allows hemopexin to interact with a specific receptor, forming a complex which is then internalized. Heme concentrations in plasma increase after hemolysis, which is associated with several pathological conditions such as reperfusion injury and ischemia.

Reconstitution Instructions: N/A

NCBI Gene Symbol: HPX

Gene ID: 3263

NCBI Accession: P02790

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Additional Information

Size:
50 μg
Country of Manufacturing Origin:
USA
Country of Animal Origin:
USA
Gene Source:
Human
Recombinant:
Yes
Source:
Human cells
Purity by SDS-PAGE:
> 95%
Assay:
SDS-PAGE
Purity:
N/A
Assay 2:
N/A
Endotoxin Level:
< 1.0 EU per/μg
Activity (Specifications/test method):
N/A
Biological activity:
N/A
Results:
N/A
Molecular Weight:
51 kDa
Storage Temperature:
-20°C
Shelf Life:
12 months
Appearance:
Liquid
Handling:
Centrifuge the vial prior to opening.
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