Human CellExp™ HDAC11, Human Recombinant, Active

Human CellExp™ HDAC11, Human Recombinant, Active is available at Gentaur for Next week delivery.

A member of the Class IV HDAC subfamily

Biomolecule/Target: HDAC11

Alternates names: HDAC11, HD11, Histone Deacetylase 11

Synonyms: HDAC11, HD11, Histone Deacetylase 11

Background Information: HDAC11 is a 39kDa protein and belongs to the Histone Deacetylase Class IV subfamily. The enzyme is primarily localized in the nucleus and shows high expression in specific tissues like brain, heart, skeletal muscle and kidney. It is the newest member of the HDAC family and hence very little is known about its functional role. Initial studies identified HDAC11 as a negative regulator of IL-10 production in APC cells. A recent study shows that HDAC11 is the most efficient fatty acid deacetylase of the HDAC family with catalytic efficiencies towards dodecanoylated and myristoylated substrates exceeding 70,000 M-1 s -1. Increasing body of evidence indicate a possible involvement of HDAC11 in diverse pathophysiological processes including immunomodulation, cancer pathogenesis, cellular differentiation etc

Reconstitution Instructions: N/A

NCBI Gene Symbol: HDAC11

Gene ID: 79885

NCBI Accession: Q96DB2