Human CellExp™ Gremlin / GREM1, Fc Tag, Human recombinant

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SKU:
P1123-50
$719.07
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Description

Human CellExp™ Gremlin / GREM1, Fc Tag, Human recombinant is available at Gentaur for Next week delivery.

A TGF-β antagonist

Biomolecule/Target: Grem1

Alternates names: GREM1, CKTSF1B1, DAND2, DRM, PIG2

Synonyms: GREM1, CKTSF1B1, DAND2, DRM, PIG2

Background Information: Gremlin is also known as Cysteine knot superfamily 1, BMP antagonist 1 (CKTSF1B1), DAN domain family member 2 (DAND2), Down-regulated in Mos-transformed cells protein (DRM), Increased in high glucose protein 2 (IHG-2), Cell proliferation-inducing gene 2 protein (PIG2) or Gremlin-1 (GREM1), which is highly expressed in small intestine, fetal brain and colon. Gremlin / GREM-1 interacts with SLIT1 and SLIT2 in a glycosylation-dependent manner. Gremlin may play an important role during carcinogenesis and metanephric kidney organogenesis, as a BMP antagonist required for early limb outgrowth and patterning in maintaining the FGF4-SHH feedback loop. Gremlin down-regulates the BMP4 signaling in a dose-dependent manner and acts as inhibitor of monocyte chemotaxis.

Reconstitution Instructions: Reconstitute in sterile deionized water to the desired protein concentration.

NCBI Gene Symbol: Grem1

Gene ID: 23892

NCBI Accession: O70326

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Additional Information

Size:
50 μg
Country of Manufacturing Origin:
USA
Country of Animal Origin:
USA
Gene Source:
Human
Recombinant:
Yes
Source:
HEK 293 cells
Purity by SDS-PAGE:
> 95%
Assay:
SDS-PAGE
Purity:
N/A
Assay 2:
N/A
Endotoxin Level:
< 1.0 EU per/μg
Activity (Specifications/test method):
Measured by its binding ability in a functional ELISA.
Biological activity:
Immobilized Human BMP-2, at 2 μg/Ml (100 μL/well) can bind Human Gremlin, Fc Tag with a linear range of 0.8-80 ng/mL.
Results:
N/A
Molecular Weight:
44.2 kDa
Storage Temperature:
-20°C
Shelf Life:
12 months
Concentration:
N/A
Appearance:
Lyophilized
Handling:
Centrifuge the vial prior to opening.
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