Human CellExp™ Glypican 2 / GPC2, Mouse Recombinant

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SKU:
P1488-50
$183
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Description

Human CellExp™ Glypican 2 / GPC2, Mouse Recombinant is available at Gentaur for Next week delivery.

Cell surface proteoglycan that bears heparan sulfate.

Biomolecule/Target:

Alternates names: Glypican 2, GPC2

Synonyms: Glypican 2, GPC2

Background Information: Glypican 2 (GPC2), also known cerebroglycan, is a glycophosphatidylinositol-linked integral membrane heparan sulfate proteoglycan found in the developing nervous system. Cerebroglycan participates in cell adhesion and is thought to regulate the growth and guidance of axons. Cerebroglycan has especially high affinity for laminin-1. GPC2 silencing inactivates Wnt/β-catenin signaling and reduces the expression of N-Myc, an oncogenic driver of neuroblastoma tumorigenesis. Immunotoxins and chimeric antigen receptor (CAR) T cells targeting GPC2 inhibit neuroblastoma growth in mouse models. A GPC3 specific antibody drug conjugate (ADC) can also inhibit neuroblastoma cell proliferation.

Reconstitution Instructions: Reconstitute in sterile deionized water to the desired protein concentration.

NCBI Gene Symbol: Gpc2

Gene ID: 71951

NCBI Accession: Q8BKV1

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Additional Information

Size:
50 µg
Adwords:
False
Country of Manufacturing Origin:
USA
Country of Animal Origin:
USA
Gene Source:
Mouse
Recombinant:
True
Source:
HEK 293 cells
Purity by SDS-PAGE:
>95%
Endotoxin Level:
Less than 1.0 EU per μg by the LAL method.
Activity (Specifications/test method):
Immobilized Recombinant Human Midkine Protein, CF at 2 μg/mL (100 μL/well) can bind Mouse Glypican 2, His Tag with a linear range of 2-13 ng/mL
Molecular Weight:
This protein carries a polyhistidine tag at the C-terminus. The protein has a calculated MW of 60.6 kDa. The protein migrates as 35-40 kDa under reducing (R) condition (SDS-PAGE).
Storage Temperature:
-20°C
Shelf Life:
12 months
Appearance:
Lyophilized powder
Handling:
Centrifuge the vial prior to opening.
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