BioVision Proteins
Human CellExp™ Glypican 2 / GPC2, Mouse Recombinant
- SKU:
- P1488-50
Description
Human CellExp™ Glypican 2 / GPC2, Mouse Recombinant is available at Gentaur for Next week delivery.
Cell surface proteoglycan that bears heparan sulfate.
Biomolecule/Target:
Alternates names: Glypican 2, GPC2
Synonyms: Glypican 2, GPC2
Background Information: Glypican 2 (GPC2), also known cerebroglycan, is a glycophosphatidylinositol-linked integral membrane heparan sulfate proteoglycan found in the developing nervous system. Cerebroglycan participates in cell adhesion and is thought to regulate the growth and guidance of axons. Cerebroglycan has especially high affinity for laminin-1. GPC2 silencing inactivates Wnt/β-catenin signaling and reduces the expression of N-Myc, an oncogenic driver of neuroblastoma tumorigenesis. Immunotoxins and chimeric antigen receptor (CAR) T cells targeting GPC2 inhibit neuroblastoma growth in mouse models. A GPC3 specific antibody drug conjugate (ADC) can also inhibit neuroblastoma cell proliferation.
Reconstitution Instructions: Reconstitute in sterile deionized water to the desired protein concentration.
NCBI Gene Symbol: Gpc2
Gene ID: 71951
NCBI Accession: Q8BKV1
Additional Information
Size: |
50 µg |
Adwords: |
False |
Country of Manufacturing Origin: |
USA |
Country of Animal Origin: |
USA |
Gene Source: |
Mouse |
Recombinant: |
True |
Source: |
HEK 293 cells |
Purity by SDS-PAGE: |
>95% |
Endotoxin Level: |
Less than 1.0 EU per μg by the LAL method. |
Activity (Specifications/test method): |
Immobilized Recombinant Human Midkine Protein, CF at 2 μg/mL (100 μL/well) can bind Mouse Glypican 2, His Tag with a linear range of 2-13 ng/mL |
Molecular Weight: |
This protein carries a polyhistidine tag at the C-terminus. The protein has a calculated MW of 60.6 kDa. The protein migrates as 35-40 kDa under reducing (R) condition (SDS-PAGE). |
Storage Temperature: |
-20°C |
Shelf Life: |
12 months |
Appearance: |
Lyophilized powder |
Handling: |
Centrifuge the vial prior to opening. |