Human CellExp™ Fc gamma RIV / CD16-2, Mouse recombinant

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SKU:
P1426-50
$183
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Description

Human CellExp™ Fc gamma RIV / CD16-2, Mouse recombinant is available at Gentaur for Next week delivery.

Plays a role in promoting bone resorption by enhancing osteoclast differentiation following binding to IgG2a.

Biomolecule/Target:

Alternates names: Fc gamma RIV, CD16-2, Fcgr4

Synonyms: Fc gamma RIV, CD16-2, Fcgr4

Background Information: FcgR4 (Low affinity immunoglobulin gamma Fc region receptor IV) is also known as CD16-2, FcgammaRIV, receptor for the Fc region of immunoglobulin gamma. Also acts as a receptor for the Fc region of immunoglobulin epsilon. Binds with intermediate affinity to both IgG2a and IgG2b. Does not display binding to IgG1 or IgG3. Plays a role in promoting bone resorption by enhancing osteoclast differentiation following binding to IgG2a. Binds with low affinity to both the a and b allotypes of IgE. Has also been shown to bind to IgE allotype a only but not to allotype b. Binding to IgE promotes macrophage-mediated phagocytosis, antigen presentation to T cells, production of proinflammatory cytokines and the late phase of cutaneous allergic reactions.

Reconstitution Instructions: Reconstitute in sterile deionized water to the desired protein concentration.

NCBI Gene Symbol: Fcgr4

Gene ID: 246256

NCBI Accession: A0A0B4J1G0

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Additional Information

Size:
50 µg
Adwords:
False
Country of Manufacturing Origin:
USA
Country of Animal Origin:
USA
Gene Source:
Mouse
Recombinant:
True
Source:
HEK 293 Cells
Purity by SDS-PAGE:
>90%
Assay:
SDS-PAGE
Endotoxin Level:
Less than 1.0 EU per μg by the LAL method.
Molecular Weight:
This protein carries a polyhistidine tag at the C-terminus. The protein has a calculated MW of 22.8 kDa. The protein migrates as 28-35 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
Storage Temperature:
-20ºC
Shelf Life:
12 months
Appearance:
Lyophilized powder
Handling:
Centrifuge the vial prior to opening.
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