Human CellExp™ Fc gamma RIV / CD16-2, Mouse recombinant

Human CellExp™ Fc gamma RIV / CD16-2, Mouse recombinant is available at Gentaur for Next week delivery.

Plays a role in promoting bone resorption by enhancing osteoclast differentiation following binding to IgG2a.

Biomolecule/Target:

Alternates names: Fc gamma RIV, CD16-2, Fcgr4

Synonyms: Fc gamma RIV, CD16-2, Fcgr4

Background Information: FcgR4 (Low affinity immunoglobulin gamma Fc region receptor IV) is also known as CD16-2, FcgammaRIV, receptor for the Fc region of immunoglobulin gamma. Also acts as a receptor for the Fc region of immunoglobulin epsilon. Binds with intermediate affinity to both IgG2a and IgG2b. Does not display binding to IgG1 or IgG3. Plays a role in promoting bone resorption by enhancing osteoclast differentiation following binding to IgG2a. Binds with low affinity to both the a and b allotypes of IgE. Has also been shown to bind to IgE allotype a only but not to allotype b. Binding to IgE promotes macrophage-mediated phagocytosis, antigen presentation to T cells, production of proinflammatory cytokines and the late phase of cutaneous allergic reactions.

Reconstitution Instructions: Reconstitute in sterile deionized water to the desired protein concentration.

NCBI Gene Symbol: Fcgr4

Gene ID: 246256

NCBI Accession: A0A0B4J1G0