BioVision Products
Human CellExp™ Fc gamma RIIIB /CD16b, human recombinant
- SKU:
- 7446-50
Description
Human CellExp™ Fc gamma RIIIB /CD16b, human recombinant is available at Gentaur for Next week delivery.
Involved in activation of the NK cells for Antibody-Dependent Cell-mediated Cytotoxicity (ADCC)
Biomolecule/Target: Fc gamma RIIIB /CD16b
Alternates names: FCGR3B, CD16B, FCG3B, FCGR3, FCG3, IGFR3
Synonyms: FCGR3B, CD16B, FCG3B, FCGR3, FCG3, IGFR3
Background Information: CD16 is a low affinity Fc receptor, and has been identified as Fc receptors FcγRIIIa (CD16a) and FcγRIIIb (CD16b). These receptors bind to the Fc portion of IgG antibodies. CD16 encoded by two different highly homologous genes in a cell type-specific manner. CD16 is found on the surface of natural killer cells, neutrophil polymorphonuclear leukocytes, monocytes and macrophages. CD16b, also known as FCGR3B and FCG3B, is expressed specifically by neutrophils and stimulated eosinophils. CD16b is the low affinity receptor for the Fc region of immunoglobulins gamma. It binds complexed or aggregated IgG and also monomeric IgG. CD16b by itself is not capable of mediating antibody-dependent cytotoxicity and phagocytosis and cannot transduce signals from outside to inside the cell but may do so by associating with cell-specific components. Soluble CD16b has a regulatory role in inflammatory processes and induces the production of pro-inflammatory cytokines.
Reconstitution Instructions: Centrifuge the vial prior to opening. Reconstitute in sterile PBS (pH 7.4). Do not vortex.
NCBI Gene Symbol: FCGR3B
Gene ID: 2215
NCBI Accession: O75015
Additional Information
Size: |
50 μg |
Country of Manufacturing Origin: |
USA |
Country of Animal Origin: |
USA |
Gene Source: |
Human |
Recombinant: |
Yes |
Source: |
HEK293 cells |
Purity by SDS-PAGE: |
≥98% |
Assay: |
SDS-PAGE |
Purity: |
N/A |
Assay 2: |
N/A |
Activity (Specifications/test method): |
N/A |
Biological activity: |
Measured by its binding ability in a functional ELISA. |
Results: |
N/A |
Molecular Weight: |
This protein is fused with 6×His tag at the C-terminus, has a calculated MW of 22 kDa. The predicted N-terminus is Gly 17. DTT-reduced Protein migrates as 38-50 kDa due to glycosylation. |
Storage Temperature: |
-20°C |
Shelf Life: |
12 months |
Concentration: |
N/A |
Appearance: |
Lyophilized |
Handling: |
Centrifuge the vial prior to opening. |