Human CellExp™ ErbB2 / HER2 / CD340, human recombinant

Human CellExp™ ErbB2 / HER2 / CD340, human recombinant is available at Gentaur for Next week delivery.

Involved in the signal transduction pathways leading to cell growth and differentiation.

Biomolecule/Target: ErbB2

Alternates names: ERBB2, CD340, HER-2/neu, HER2, MLN19, NEU, NGL, TKR1

Synonyms: ERBB2, CD340, HER-2/neu, HER2, MLN19, NEU, NGL, TKR1

Background Information: Human Epidermal growth factor Receptor 2 (HER2) is also called ERBB2, HER-2, HER-2 /neu, NEU, NGL, TKR1 and c-erb B2, and is a protein giving higher aggressiveness in breast cancers. It is a member of the ErbB protein family, more commonly known as the epidermal growth factor receptor family. HER2 is a cell membrane surface-bound receptor tyrosine kinase and is normally involved in the signal transduction pathways leading to cell growth and differentiation. HER2 is thought to be an orphan receptor, with none of the EGF family of ligands able to activate it. Approximately 30% of breast cancers have an amplification of the HER2 gene or overexpression of its protein product. Overexpression of this receptor in breast cancer is associated with increased disease recurrence and worse prognosis. HER2 appears to play roles in development, cancer, communication at the neuromuscular junction and regulation of cell growth and differentiation.

Reconstitution Instructions: Centrifuge the vial prior to opening. Reconstitute in sterile PBS, pH 7.4 to a concentration of 50 µg/ml. Do not vortex. This solution can be stored at 2-8°C for up to 1 month. For extended storage, it is recommended to store at -20°C.

NCBI Gene Symbol: ErbB2

Gene ID: 2064

NCBI Accession: P04626