Human CellExp™ DNAM-1 / CD226, Fc Tag, Human Recombinant

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SKU:
P1494-50
€185
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Description

Human CellExp™ DNAM-1 / CD226, Fc Tag, Human Recombinant is available at Gentaur for Next week delivery.

Mediates cellular adhesion of platelets and megakaryocytic cells to vascular endothelial cells

Biomolecule/Target:

Alternates names: DNAM1, CD226, PTA1

Synonyms: DNAM1, CD226, PTA1

Background Information: DNAX accessory molecule 1 (DNAM-1), a single-pass type I membrane protein, is also known as CD226 antigen and platelet and T cell activation antigen 1 (PTA1), which contains 2 Ig-like C2-type (immunoglobulin-like) domains. DNAM-1 is a ~65 kDa glycoprotein expressed on the surface of natural killer cells, platelets, monocytes and a subset of T cells. DNAM-1 mediates cellular adhesion to other cells bearing its ligands, CD112 and CD155, and cross-linking DNAM-1 with antibodies causes cellular activation. Furthermore, DNAM-1 can interact with PVR and PVRL2.

Reconstitution Instructions: Reconstitute in sterile deionized water to the desired protein concentration.

NCBI Gene Symbol: CD226

Gene ID: 10666

NCBI Accession: NP_006557

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Additional Information

Size:
50 µg
Adwords:
False
Country of Manufacturing Origin:
USA
Country of Animal Origin:
USA
Gene Source:
Human
Recombinant:
True
Source:
HEK 293 cells
Purity by SDS-PAGE:
>95%
Assay:
SDS-PAGE
Endotoxin Level:
Less than 1.0 EU per μg by the LAL method.
Activity (Specifications/test method):
Immobilized Rhesus macaque CD155 at 5 μg/mL (100 μL/well) can bind Human DNAM-1, Fc Tag with a linear range of 2-31 ng/mL
Molecular Weight:
This protein carries a human IgG1 Fc tag at the C-terminus. The protein has a calculated MW of 52.6 kDa. The protein migrates as 66-90 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
Storage Temperature:
-20ºC
Shelf Life:
12 months
Appearance:
Lyophilized powder
Handling:
Centrifuge the vial prior to opening.
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