Description
Human CellExp™ CD8b, Human Recombinant is available at Gentaur for Next week delivery.
Integral membrane glycoprotein that plays an essential role in the immune response
Biomolecule/Target: CD8b
Alternates names: T cell surface glycoprotein CD8 beta chain, T lymphocyte surface glycoprotein beta chain, CD8b antigen, CD8 antigen beta polypeptide 1 (p37), CD8 beta, CD8b, CD8B_HUMAN, CD8B1, Leu2, Ly3, LYT3, MGC119115, P37
Synonyms: T cell surface glycoprotein CD8 beta chain, T lymphocyte surface glycoprotein beta chain, CD8b antigen, CD8 antigen beta polypeptide 1 (p37), CD8 beta, CD8b, CD8B_HUMAN, CD8B1, Leu2, Ly3, LYT3, MGC119115, P37
Background Information: The T-cell surface glycoprotein CD8 beta chain, also called CD8 beta (CD8b), P37 or LEU2 is a cell surface glycoprotein found on most cytotoxic T lymphocytes that mediates efficient cell-cell interactions within the immune system. It plays an essential role in the immune response and serves multiple functions in responses against both external and internal offenses. Being a member of functional coreceptors, CD8 functions either as a homodimer composed of two alpha chains, or a heterodimer composed of one alpha and one beta chain. Both alpha and beta chains share significant homology to immunoglobulin variable light chains. In T-cells, CD8b functions primarily as a coreceptor for class I MHC molecules. It initiates different intracellular signaling pathways by phosphorylating various substrates ultimately leading to lymphokine production, motility, adhesion and activation of cytotoxic T-lymphocytes (CTLs). Additionally, CD8b plays a critical role in thymic selection of CD8+ T-cells. CD8b is thought to play a role in the process of T-cell mediated killing.
Reconstitution Instructions: Centrifuge the vial prior to opening. Reconstitute in distilled water.
NCBI Gene Symbol: CD8B
Gene ID: 926
NCBI Accession: P10966
Additional Information
Size: |
50 μg |
Country of Manufacturing Origin: |
USA |
Country of Animal Origin: |
USA |
Gene Source: |
Human |
Recombinant: |
Yes |
Source: |
HEK293 cells |
Purity by SDS-PAGE: |
≥95% |
Assay: |
SDS-PAGE |
Purity: |
N/A |
Assay 2: |
N/A |
Endotoxin Level: |
N/A |
Activity (Specifications/test method): |
N/A |
Biological activity: |
N/A |
Results: |
N/A |
Molecular Weight: |
18 kDa |
Storage Temperature: |
-20°C |
Shelf Life: |
12 months |
Concentration: |
N/A |
Appearance: |
Lyophilized |
Handling: |
Centrifuge the vial prior to opening. |