Human CellExp™ CD73 / NT5E, Human recombinant

Human CellExp™ CD73 / NT5E, Human recombinant is available at Gentaur for Next week delivery.

Enzyme that convert AMP to adenosine

Biomolecule/Target: CD73 / NT5E

Alternates names: CD73, NT5E, 5'-Nucleotidase, 5'-NT, NT5, NTE

Synonyms: CD73, NT5E, 5'-Nucleotidase, 5'-NT, NT5, NTE

Background Information: 5'-nucleotidase (5'-NT), also known as ecto-5'-nucleotidase or CD73 (cluster of differentiation 73), is an enzyme that is encoded by the NT5E gene. CD73 commonly serves to convert AMP to adenosine. Ecto-5-prime-nucleotidase (5-prime-ribonucleotide phosphohydrolase) catalyzes the conversion at neutral pH of purine 5-prime mononucleotides to nucleosides, the preferred substrate being AMP. Other forms of 5-prime nucleotidase exist in the cytoplasm and lysosomes and can be distinguished from ecto-NT5 by their substrate affinities, requirement for divalent magnesium ion, activation by ATP, and inhibition by inorganic phosphate. Rare allelic variants are associated with a syndrome of adult-onset calcification of joints and arteries (CALJA) affecting the iliac, femoral, and tibial arteries reducing circulation in the legs and the joints of the hands and feet causing pain.

Reconstitution Instructions: Centrifuge the vial prior to opening. Reconstitute in sterile deionized water, pH 7.4 to a concentration of 50 µg/ml. Do not vortex. It is recommended to store at -20°C.

NCBI Gene Symbol: NT5E

Gene ID: 4907

NCBI Accession: P21589-1