BioVision Products
Human CellExp™ BMP-4, Human Recombinant
- SKU:
- 6445-50
Description
Human CellExp™ BMP-4, Human Recombinant is available at Gentaur for Next week delivery.
A protein involved in bone and cartilage development
Biomolecule/Target:
Alternates names: BMP4, ZYME, BMP2B, BMP2B1
Synonyms: Human Cellexp Human Recombinant BMP-4
Background Information: BMP4 belongs to the transforming growth factor-beta (TGFβ) superfamily. As implied by their name, BMPs promote and regulate bone development, growth, remodeling and repair, in both prenatal development and postnatal growth of eye, heart, kidney, skin, and other tissues. BMP-4 plays an important role in the onset of endochondral bone formation in humans, and a reduction in expression has been associated with a variety of bone diseases, including the heritable disorder Fibrodysplasia Ossificans Progressiva. Alternative splicing in the 5' untranslated region of this gene has been described and three variants are described, all encoding an identical protein.
Reconstitution Instructions: Reconstitute in sterile 4 mM HCl containing 0.1% endotoxin-free recombinant human serum albumin.
NCBI Gene Symbol: BMP4
Gene ID: 652
NCBI Accession: P12644
Additional Information
Size: |
50 μg |
Country of Manufacturing Origin: |
USA |
Country of Animal Origin: |
USA |
Gene Source: |
Human |
Recombinant: |
Yes |
Source: |
Human 293 cell expressed |
Purity by SDS-PAGE: |
≥95% |
Assay: |
SDS-PAGE |
Purity: |
N/A |
Assay 2: |
N/A |
Endotoxin Level: |
< 1.0 EU per 1 μg of protein |
Activity (Specifications/test method): |
N/A |
Biological activity: |
ED₅₀ is typically 2 to 10 ng/mL. The specific activity was determined by the dose dependent induction of alkaline phosphatase production in the ATDC-5 cell line (Mouse chondrogenic cell line). |
Results: |
2 to 10 ng/ml |
Molecular Weight: |
34 kDa, homodimer, glycosylated. |
Storage Temperature: |
-20°C |
Shelf Life: |
12 months |
Concentration: |
N/A |
Appearance: |
Lyophilized |
Handling: |
Centrifuge the vial prior to opening. |