Human CellExp™ B7-H6, human recombinant

Human CellExp™ B7-H6, human recombinant is available at Gentaur for Next week delivery.

Triggers NCR3-dependent natural killer cell activation.

Biomolecule/Target: NCR3LG1

Alternates names: B7-H6, Natural cytotoxicity triggering receptor 3 ligand 1, B7H6, B7 homolog 6, NCR3LG1

Synonyms: Natural cytotoxicity triggering receptor 3 ligand 1

Background Information: B7-H6 is a glycosylated member of the B7 family of immune costimulatory proteins. Orthologs in mouse and rat have not been identified. The Ig-like V domain mediates 1:1 stoichiometric binding of B7-H6 to NKp30 expressed on NK cells. It does not show binding to NKp44, NKp46, or NKG2D. Ligation of NKp30 by B7-H6 induces NK cell activation and target cell cytolysis. B7-H6 is expressed on a wide range of hematopoietic, carcinoma, and melanoma tumor cells, which is consistent with the detection of NKp30 binding sites on many tumors. The expression of NKp30 ligands on tumor cells correlates with tumor cell sensitivity to NKp30-dependent cell lysis.

Reconstitution Instructions: Reconstitute in 1X PBS to the desired protein concentration.

NCBI Gene Symbol: NCR3LG1

Gene ID: 374383

NCBI Accession: Q68D85