Human CellExp™ Acid Sphingomyelinase, Human Recombinant

Human CellExp™ Acid Sphingomyelinase, Human Recombinant is available at Gentaur for Next week delivery.

Catalyzes the hydrolysis of sphingomyelin to ceramide and phosphorylcholine

Biomolecule/Target:

Alternates names: Sphingomyelin phosphodiesterase, aSMase, acid sphingomyelinase, SMPD1, ASM, EC:3.1.4.12

Synonyms: Sphingomyelin phosphodiesterase, aSMase, acid sphingomyelinase, SMPD1, ASM, EC:3.1.4.12

Background Information: Sphingomyelin phosphodiesterase, which is encoded by the SMPD1 gene, is also known as acid sphingomyelinase or aSMase. There are two types of sphingomyelinases: ASM (acid), and NSM (neutral). ASM / aSMase can catalyze the hydrolysis of sphingomyelin to ceramide and phosphorylcholine with cofactor Zn2+. Ceramide, a bioactive lipid, has emerged as an important signaling molecule involved in a variety of cellular processes such as cell differentiation, apoptosis, and proliferation. Mutations in the SMPD1 gene cause Niemann–Pick disease types A and B due to deficiency in hydrolyzing sphingomyelin to ceramide. Activation of ASM can be achieved by the removal of its C terminal cysteine residue or C-terminal truncation. BioVision’s recombinant human ASM was expressed from HEK293 cells without the last three C terminal residues, and is therefore constitutively active.

Reconstitution Instructions: Centrifuge the vial prior to opening. Reconstitute in distilled water. Do not vortex.

NCBI Gene Symbol: SMPD1

Gene ID: 6609

NCBI Accession: P17405