BioVision Proteins
Human CellExp™ Acetylcholinesterase / AChE, Human Recombinant
- SKU:
- P1475-50
Description
Human CellExp™ Acetylcholinesterase / AChE, Human Recombinant is available at Gentaur for Next week delivery.
Biomolecule/Target:
Alternates names: Acetylcholinesterase (EC:3.1.1.7), AChE
Synonyms: Acetylcholinesterase (EC:3.1.1.7), AChE
Background Information: Acetylcholinesterase (AChE) is the major enzyme that hydrolyzes acetylcholine, a key neurotransmitter for synaptic transmission, into acetic acid and choline in both central and peripheral nervous systems. Mild inhibition of AChE has been shown to have therapeutic relevance in Alzheimer's disease (AD), myasthenia gravis, and glaucoma among others. In contrast, strong inhibition of AChE can lead to cholinergic poisoning. An irregular expression of AChE has also been found in different types of tumors, suggesting the involvement of AChE in the regulation of tumor development. Therefore AChE inhibitors could potentially be used in cancer treatment in future.
Reconstitution Instructions: Centrifuge the vial prior to opening. Reconstitute in sterile PBS (pH 7.4). Do not vortex.
NCBI Gene Symbol: ACHE
Gene ID: 43
NCBI Accession: P22303
Additional Information
Size: |
50 µg |
Adwords: |
False |
Country of Manufacturing Origin: |
USA |
Country of Animal Origin: |
USA |
Gene Source: |
Human |
Recombinant: |
True |
Source: |
HEK 293 cells |
Purity by SDS-PAGE: |
>95% |
Activity (Specifications/test method): |
The specific activity is > 500 U/mg. Specific activity was tested using BioVision’s Acetylcholinesterase Inhibitor Screening Kit (Catalog# K197). |
Molecular Weight: |
~70 kDa (C terminal 6×His tag) |
Storage Temperature: |
-20°C |
Shelf Life: |
12 months |
Appearance: |
Lyophilized powder |
Handling: |
Centrifuge the vial prior to opening. |