HMG-CoA Reductase Catalytic Domain (GST Tagged), human recombinant

HMG-CoA Reductase Catalytic Domain (GST Tagged), human recombinant is available at Gentaur for Next week delivery.

≥90% Pure Human recombinant GST Tagged HMG-CoA Reductase Catalytic Domain, a primary target of statins.

Biomolecule/Target: HMG-CoA Reductase

Alternates names: 3-Hydroxy-3-methylglutaryl-CoA reductase, HMGR, HMGCR

Synonyms: 3-Hydroxy-3-methylglutaryl-CoA reductase, HMGR, HMGCR

Background Information: HMG-CoA reductase (3-hydroxy-3-methyl-glutaryl-CoA reductase or HMGR) (EC 1.1.1.34) is a transmembrane protein involved in the mevalonate pathway, the metabolic pathway that produces cholesterol from acetyl-CoA. In an NADPH-dependent reaction, HMG-CoA reductase reduces HMG-CoA to generate mevalonate and CoA. Since HMG-CoA reductase catalyzes the rate limiting step in cholesterol synthesis, it is a primary target of a group of cholesterol-lowering drugs known as statins. Inhibition of HMG-CoA reductase induces expression of LDL receptors in the liver, which lowers plasma concentration of cholesterol.

Reconstitution Instructions: Briefly spin down the vial and reconstitute in 50% glycerol in PBS to 0.5-1.0 mg/ml and store at –80°C.

NCBI Gene Symbol: HMGCR

Gene ID: 3156

NCBI Accession: P04035