SIRT4 (GST-tagged), Human recombinant

SIRT4 (GST-tagged), Human recombinant is available at Gentaur for Next week delivery.

Intracellular regulatory proteins with mono-ADP-ribosyltransferase activity.

Biomolecule/Target: SIRT4

Alternates names: SIR2-like Protein 4; NAD-dependent ADP-ribosyltransferase Sirtuin 4; SIR2L4; Silent Information Regulator 4; Sirtuin 4

Synonyms: SIRT4 (GST-tagged), Human recombinant

Background Information: There are seven human sirtuins, also known as class III HDACs, which have been designated SIRT1 to SIRT7. Each is involved in various post-translational modifications by utilizing NAD dependent deacetylase and APD-ribosyltransferase activities. SIRT4 is a mitochondrial ADP-ribosyltransferase responsible for the transfer of ADP-ribose from NAD to specific substrates such as glutamate dehydrogenase (GDH). In caloric-sufficient conditions, SIRT4 ADP-ribosylates GDH, repressing its activity and correspondingly decreasing insulin secretion. There is some uncertainty about the relevance of sirtuin ribosyl transferase activity due to its very slow rate, which is about 500 times lower than the corresponding deacetylation reaction (for those that have been characterized). SIRT4 is found in many tissues, but is specifically enriched in the kidney, heart, brain, and liver.

Reconstitution Instructions: N/A

NCBI Gene Symbol: SIRT4

Gene ID: 23409

NCBI Accession: Q9Y6E7