HER2, Active, Human Recombinant

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SKU:
8011-50
€185
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Description

HER2, Active, Human Recombinant is available at Gentaur for Next week delivery.

Active, Human Recombinant Her2 for functional assays.

Biomolecule/Target: HER2

Alternates names: HER, v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog

Synonyms: HER, v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog

Background Information: HER2 gene encodes a cell-surface glycoprotein tyrosine kinase receptor with extensive homology to the epidermal growth factor receptor. HER2 is an oncogene and overexpression of unaltered HER2 coding sequences in NIH 3T3 cells results in cellular transformation and tumorigenesis. HER2 is amplified in about 30% of primary human breast malignancies and overexpression of HER2 is associated with the most aggressive tumors that show uncontrolled proliferation, resistance to apoptosis and increased motility.

Reconstitution Instructions: N/A

NCBI Gene Symbol: HER2

Gene ID: 2064

NCBI Accession: NM_004448.

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Additional Information

Size:
50 µg
Country of Manufacturing Origin:
USA
Country of Animal Origin:
USA
Gene Source:
Human
Recombinant:
Yes
Source:
E. coli
Purity by SDS-PAGE:
N/A
Assay:
N/A
Purity:
N/A
Assay 2:
N/A
Endotoxin Level:
N/A
Activity (Specifications/test method):
> 20 U/mg
Biological activity:
> 20 U/mg
Results:
> 20 U/mg
Molecular Weight:
~ 100 kDa protein in SDS-PAGE under reducing conditions (aa 676 - end, N terminal-GST tag)
Storage Temperature:
-80°C
Shelf Life:
12 months
Concentration:
0.2 mg/ml
Appearance:
Liquid
Handling:
Centrifuge the vial prior to opening.
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