GAPDH, human recombinant

GAPDH, human recombinant is available at Gentaur for Next week delivery.

Involved in glycolysis

Biomolecule/Target:

Alternates names: Glyceraldehyde-3-phosphate dehydrogenase (GAPDH) (EC 1.2.1.12) (Peptidyl-cysteine S-nitrosylase GAPDH) (EC 2.6.99.-)

Synonyms: GAPDH, Glyceraldehyde 3-phosphate dehydrogenase

Background Information: Glyceraldehyde-3-Phosphate Dehydrogenase (GAPDH) is a catalytic enzyme normally known to play a role in glycolysis. GAPDH exists as a tetramer composed of 36-kDa subunits and has a range of intracellular functions. GAPDH catalyzes the reversible reduction of 1,3-bisphosphoglycerate to glyceraldehyde 3-phosphophate in the presence of NADPH. Besides functioning as a glycolytic enzyme in cytoplasm, GAPDH has function in intracellular processes such as membrane fusion, microtubule bundling, phosphotransferase activity, nuclear RNA export, DNA replication and DNA repair. GAPDH catalyzes a vital energy-yielding step in carbohydrate metabolism, the reversible oxidative phosphorylation of glyceraldehyde-3-phosphate in the presence of inorganic phosphate and nicotinamide adenine dinucleotide (NAD). The enzyme exists as a tetramer of identical chains. Recombinant human GAPDH produced in E.Coli is a single, non-glycosylated polypeptide chain containing 335 amino acids and having a molecular mass of 36 kDa. The GAPDH is purified by proprietary chromatographic techniques.

Reconstitution Instructions: N/A

NCBI Gene Symbol: GD3

Gene ID: 2597

NCBI Accession: P04406.3