EZCyp™ Active Human Cytochrome P450 2D6

EZCyp™ Active Human Cytochrome P450 2D6 is available at Gentaur for Next week delivery.

Unique, cost-effective CYP2D6 catalytic system with active recombinant human CYP2D6 coexpressed with the active NADPH reductase in a semipermeable membrane system.

Biomolecule/Target: EZCyp™ Active Human CYP2D6

Alternates names: Cytochrome P450 2D6, Cyt2D6, CYPIID6, P450-DB1, Debrisoquine 4-hydroxylase, Active CYP2D6, human cyp2d, recombinant CYP2D6, CYP2D6, CPD6, CYP2D, CYP2DL1, P450C2D, MGC120389, MGC120390, LKM1, liver/kidney microsomal antigen 1

Synonyms: Cytochrome P450 2D6, Cyt2D6, CYPIID6, P450-DB1, Debrisoquine 4-hydroxylase, Active CYP2D6, human cyp2d, recombinant CYP2D6, CYP2D6, CPD6, CYP2D, CYP2DL1, P450C2D, MGC120389, MGC120390, LKM1, liver/kidney microsomal antigen 1

Background Information: Cytochrome P450 2D6 (CYP2D6, EC 1.14.14.1) is a member of the cytochrome P450 monooxidase (CYP) family of microsomal xenobiotic metabolism enzymes. CYPs are membrane-bound hemeproteins responsible for Phase I biotransformation reactions, in which lipophilic drugs and other xenobiotic compounds are converted to more hydrophilic products to facilitate excretion from the body. CYP2D6 catalyzes oxidation of lipophilic bases with an aromatic ring and a nitrogen atom and is highly expressed in liver and brain tissue. The enzyme is responsible for metabolism of nearly 25% of all small molecule drugs commonly used by humans, particularly psychiatric drugs such as antidepressants, antipsychotics and stimulants. BioVision’s EZCypTM 2D6 is a permeabilized and stabilized dried yeast powder preparation containing recombinant human CYP2D6 and recombinant human P450 NADPH oxidoreductase co expressed in the same preparation.

Reconstitution Instructions: 100 mM Potassium Phosphate buffer, pH 7.7

NCBI Gene Symbol: CYP2D6

Gene ID: 1565

NCBI Accession: P10635