Caspases Group III, Active Human

Caspases Group III, Active Human is available at Gentaur for Next week delivery.

Set of recombinant proteases involved in apoptosis

Biomolecule/Target:

Alternates names: N/A

Synonyms: Caspases Group III, Active Human

Background Information: Caspase family consists of more than 10 members. Based on their extended substrate specificities, these enzymes were divided into three major groups: Group I (contains caspase-1,-4,-5), Group II (contains caspase-2,-3,-7), and Group III (contains caspase-6,-8,-9,-10). Evidences have suggested that Group I caspases are involved primarily in the production of inflammatory cytokines, while group II and III enzymes function in apoptosis as effectors and upstream activators, respectively. The Group III recombinant caspases were expressed in E. coli and routinely tested for their ability to enzymatically cleave the substrate VEID-pNA (for caspase-6), IETD-pNA (for caspase-8 & -10) and LEHD-pNA (for caspase-9), respectively.

Reconstitution Instructions: Reconstitute to 1 unit per µl in PBS containing 15% glycerol

NCBI Gene Symbol: CASP6 CASP8 CASP9 CASP10

Gene ID: CASP6- 839 CASP8- 841 CASP9- 842 CASP10- 843

NCBI Accession: CASP6- P55212 CASP8- Q14790 CASP9- P55211 CASP10- Q92851