C5a (His-Tag), murine recombinant

C5a (His-Tag), murine recombinant is available at Gentaur for Next week delivery.

An anaphylatoxin

Biomolecule/Target:

Alternates names: Complement Fragments C5a, C5a anaphylatoxin chemotactic receptor

Synonyms: Complement Fragments C5a

Background Information: Mouse complement C5a is a 77-amino acid peptide generated during complement activation from the α-chain of complement C5. Mouse C5a shares 60% and 82% amino acid sequence identity to human and rat C5a, respectively. C5a binds to a signaling G-protein coupled receptor (GPCR) (C5aR/CD88), inducing neutrophil chemotaxis and endothelial cell activation. It also triggers an oxidative burst in macrophages and neutrophils, and induces release of histamine in basophils and mast cells. The 9 kDa mouse C5a protein expressed in E. coli contains a N-terminal His-Tag sequence.

Reconstitution Instructions: Reconstitute to a concentration of 1.0 mg/ml in ice-cold H₂O containing 2.5 mg/ml BSA. The solution should be aliquoted and immediately stored at -70°C.

NCBI Gene Symbol: C5a

Gene ID: 15139

NCBI Accession: NP_034536