Description
BMP-12/GDF-7, human recombinant is available at Gentaur for Next week delivery.
A protein with functions in regulating inflammatory and apoptotic pathways
Biomolecule/Target: BMP-12/GDF-7
Alternates names: BMP-12/GDF-7, BMP12/GDF7, BMP 12/GDF 7,
Synonyms: bone morphogenetic protein 12, BMP12, BMP 12
Background Information: BMPs (bone morphogenetic proteins) belong to the TGF-β superfamily of structurally related signaling proteins. As implied by their name, BMPs promote and regulate bone development, growth, remodeling and repair, in both prenatal development and postnatal growth of eye, heart, kidney, skin, and other tissues. BMP-12 is highly conserved across species. BMP-12 regulates chondrogenesis, bone morphogenesis, and neuron differentiation. Recombinant human BMP-12 is a 27 kDa disulfide-linked homodimer containing two 122 amino acid polypeptide chains.
Reconstitution Instructions: Reconstitute to a concentration of 0.1-1.0 mg/ml in H₂O containing BSA (50 mg BSA per 1 mg of protein). This solution can then be diluted into other aqueous buffers.
NCBI Gene Symbol: BMP12/GDF7
Gene ID: 151449
NCBI Accession: BAD07014
Additional Information
Size: |
20 μg |
Adwords: |
Yes |
Country of Manufacturing Origin: |
USA |
Country of Animal Origin: |
USA |
Gene Source: |
Human |
Recombinant: |
Yes |
Source: |
E. coli |
Purity by SDS-PAGE: |
≥98% |
Assay: |
SDS-PAGE |
Purity: |
≥98% |
Assay 2: |
HPLC |
Endotoxin Level: |
<0.1 ng/μg |
Activity (Specifications/test method): |
N/A |
Biological activity: |
The protein is biologically active as determined by its ability to induce alkaline phosphatase production by ADTC5 mouse chondrogenic cells. The ED₅₀ for this effect is typically 0.2 – 2.5 µg/ml. |
Results: |
0.2 – 2.5 µg/ml |
Molecular Weight: |
27 kDa |
Storage Temperature: |
-20°C |
Shelf Life: |
12 months |
Concentration: |
N/A |
Appearance: |
Lyophilized protein |
Handling: |
Centrifuge the vial prior to opening. |