B7-H4 /VTCN1, mouse recombinant

B7-H4 /VTCN1, mouse recombinant is available at Gentaur for Next week delivery.

Negatively regulates T-cell-mediated immune response and is involved in promoting epithelial cell transformation

Biomolecule/Target: Vtcn1

Alternates names: V-set Domain-containing T Cell Activation Inhibitor 1, VTCN1, B7h.5, Immune Costimulatory Protein B7-H4, T Cell Costimulatory Molecule B7x, Protein B7S2

Synonyms: V-set Domain-containing T Cell Activation Inhibitor 1, VTCN1, B7h.5, Immune Costimulatory Protein B7-H4, T Cell Costimulatory Molecule B7x, Protein B7S2

Background Information: B7-H4 is a B7 family member that negatively regulates T cell immunity by inhibiting T cell proliferation, cytokine production and cell cycle progression. In vitro, B7-H4 inhibits CD4+ and CD8+ T cell proliferation, cytokine production and generation of alloreactive cytotoxic T cells (CTLs). In vivo, blockade of endogenous B7-H4 by specific monoclonal antibody promotes T cell responses. B7-H4 ia an important negative regulator of innate immunity through growth inhibition of neutrophils. B7-H4 is expressed on some tumor cancer cells. The role of B7-H4 in tumor progression may be to transform precancerous cells and then protect them from immunosurveillance.

Reconstitution Instructions: Reconstitute with 100 µl sterile water.

NCBI Gene Symbol: Vtcn1

Gene ID: 242122

NCBI Accession: Q7TSP5