Active PAD4, Human Recombinant

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SKU:
P1720-50
€185
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Description

Active PAD4, Human Recombinant is available at Gentaur for Next week delivery.

Protein arginine deiminase associated with rheumatoid arthritis

Biomolecule/Target:

Alternates names:

Synonyms: Peptidyl Arginine Deiminase 4; PDI5; Peptidyl Arginine Deiminase, Type IV; Peptidyl Arginine Deiminase, Type V; Protein-Arginine Deiminase Type IV; Protein-Arginine Deiminase Type-4; EC 3.5.3.15; HL-60 PAD; PADI5; PDI4; PAD; Peptidylarginine Deiminase IV; PADI-H Protein; PADI4

Background Information: Protein arginine deiminases (PADs) are a family of guanidine-modifying enzymes that catalyze the post-translational modification of target proteins by converting arginine to citrulline. Excessive citrullination of proteins may result in disease states. PAD4 (also known as PADI5) is expressed in neutrophils and in a variety of tissues. PAD4 is known to citrullinate histones, which initiates chromatin decondensation in neutrophils and the subsequent release of neutrophil extracellular traps (NETs), which leads to a lytic form of cell death known as NETosis. The presence of serum PAD4 autoantibodies has been associated with rheumatoid arthritis.

Reconstitution Instructions:

NCBI Gene Symbol:

Gene ID: 23569

NCBI Accession: Q9UM07

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Additional Information

Size:
50 µg
Adwords:
False
Country of Manufacturing Origin:
USA
Country of Animal Origin:
USA
Gene Source:
Human
Recombinant:
True
Source:
E.coli
Purity by SDS-PAGE:
≥ 85% by SDS-PAGE
Activity (Specifications/test method):
Activity output measured by the production of ammonium ions when enzyme acts on N-benzoyl-L-arginine ethyl ester (BAEE) substrate
Molecular Weight:
75.8 kDa
Storage Temperature:
-80°C
Shelf Life:
12 months
Appearance:
Liquid protein
Handling:
Centrifuge the vial prior to opening.
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