Active BCL2L1 Protein, human recombinant

Active BCL2L1 Protein, human recombinant is available at Gentaur for Next week delivery.

A Potent inhibitor of cell death that inhibits the activation of caspases.

Biomolecule/Target: BCL2L1

Alternates names: Bcl-2-like protein 1, Bcl2-L-1, Bcl-X, BCL2L, BCLX

Synonyms: Bcl-2-like protein 1, Bcl2-L-1, Bcl-X, BCL2L, BCLX

Background Information: Potent inhibitor of cell death. Inhibits activation of caspases. Appears to regulate cell death by blocking the voltage-dependent anion channel (VDAC) by binding to it and preventing the release of the caspase activator, CYC1, from the mitochondrial membrane. Also acts as a regulator of G2 checkpoint and progression to cytokinesis during mitosis. Isoform Bcl-X(L) also regulates presynaptic plasticity, including neurotransmitter release and recovery, number of axonal mitochondria as well as size and number of synaptic vesicle clusters. During synaptic stimulation, increases ATP availability from mitochondria through regulation of mitochondrial membrane ATP synthase F1F0 activity and regulates endocytic vesicle retrieval in hippocampal neurons through association with DMN1L and stimulation of its GTPase activity in synaptic vesicles. Isoform Bcl-X(S) promotes apoptosis.

Reconstitution Instructions: Reconstitute in sterile deionized water to a stock solution of 200 µg/mL. Solubilize for 30 to 60 minutes at room temperature with occasional gentle mixing. Carrier protein (0.1% (W/V) HSA or BSA) is recommended for further dilution and long term storage.

NCBI Gene Symbol: BCL2L1

Gene ID: 598

NCBI Accession: Q07817