Phospho-ALOX5 (Ser523) Antibody

Phospho-ALOX5 (Ser523) Antibodyis available at Gentaur for Next week Delivery.

Description: This gene encodes a member of the lipoxygenase gene family and plays a dual role in the synthesis of leukotrienes from arachidonic acid. The encoded protein, which is expressed specifically in bone marrow-derived cells, catalyzes the conversion of arachidonic acid to 5(S)-hydroperoxy-6-trans-8,11,14-cis-eicosatetraenoic acid, and further to the allylic epoxide 5(S)-trans-7,9-trans-11,14-cis-eicosatetrenoic acid (leukotriene A4). Leukotrienes are important mediators of a number of inflammatory and allergic conditions. Mutations in the promoter region of this gene lead to a diminished response to antileukotriene drugs used in the treatment of asthma and may also be associated with atherosclerosis and several cancers. Alternatively spliced transcript variants have been observed, but their full-length nature has not been determined.

Immunogen Sequence:A synthesized peptide derived from human ALOX5 around the phosphorylation site of Sersine 523.

Target Alternative Name:ALOX5, 5-LOX, Arachidonate 5-lipoxygenase

Species Reactivities:Rat, Human

Tag Line:Polyclonal antibody to detect endogenous levels of Phospho-ALOX5 (Ser523) in human and rat sample

Formulation:In phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Purification: Affinity purification

Application:Immunofluorescence (IF), Immunocytochemistry (ICC), Western Blotting, ELISA

Positive Control:/

Application And Usages:ELISA (peptide) 1:20000-1:40000, WB 1:500-1:2000, IF/ICC 1:100-1:500

Handling:The antibody solution should be gently mixed before use.