TrkB Antibody

TrkB Antibodyis available at Gentaur for Next week Delivery.

Description: Due to the various splice variants, the trk proteins exist as variably glycosylated entities with the major forms having molecular weights of 140-145 kDa, 110 kDa and the unglycosylated form of 80 kDa. trkB contains 33.3% carbohydrate by weight representing modification on 10 of 12 N-glycosylation sites. The primary ligand for trkB is BDNF which induces the phosphorylation of the protein and subsequent binding of PLC-gamma via SH2 domains. TrkB may function to modulate neuronal responses to the neurotrophins acting throμgh trkB such as BDNF.

Immunogen Sequence:Synthetic peptide surrounding amino acid 810 of human TrkB

Target Alternative Name:NTRK2 , GP145-TrkB , TRKB , Trk-B , tyrosine receptor kinase

Species Reactivities:Human, mouse, rat, chicken

Tag Line:/

Formulation:In phosphate-buffered saline (PBS) containing 30% glycerol, 0.5% BSA, 5 mM EDTA and 0.03% proclin.

Purification: Affinity purified

Application:Western blot, Immunoprecipitation, Immunofluorescence

Positive Control:/

Application And Usages:Western blotting (0.5-4 µg/ml), immunofluorescence (5-10 µg/ml). However, the optimal concentrations should be determined individually. Trk protein exists as variably glycosylated entities with the major forms having molecular weights of 140 kDa, 110 kDa, and the unglycosylated form of 80 kDa.

Handling:The antibody solution should be gently mixed before use.