Phospho-p53 Antibody

Phospho-p53 Antibodyis available at Gentaur for Next week Delivery.

Description: The p53 tumor suppressor protein plays a major role in cellular response to DNA damage and other genomic aberrations. The activation of p53 can lead to either cell cycle arrest and DNA repair or apoptosis. p53 is phosphorylated at multiple sites in vivo and by several different protein kinases in vitro. p53 can apparently be phosphorylated by ATM, ATR, and DNA-PK at Ser15; the phosphorylation impairs the ability of MDM2 to bind p53, promoting both the accumulation and functional activation of p53 in response to DNA damage.

Immunogen Sequence:KLH-conjugated synthetic peptide encompassing a sequence within the N-term region of human p53.

Target Alternative Name:TP53 , p53 , LFS1 , TRP53 , P53 , tumor protein p53 , Li-Fraumeni syndrome

Species Reactivities:Human, Rat

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Formulation:In 0.42% Potassium phosphate; 0.87% Sodium chloride; pH 7.3; 30% glycerol; and 0.01% sodium azide.

Purification: Affinity purified

Application:WB, IHC, IF

Positive Control:WB: Hela UV-treated; PC12 whole cell lysates; IHC: human breast cancer; IF: PC12 cells

Application And Usages:WB 1:500 – 1:1000; IHC 1:100 – 1:200; IF/IC 1:100 – 1:500; IP 1:10 – 1:100. However, the optimal conditions should be determined individually

Handling:The antibody solution should be gently mixed before use.