Phospho-p53 Antibody

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SKU:
3515-100
$431
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Description

Phospho-p53 Antibodyis available at Gentaur for Next week Delivery.

Description: The p53 tumor suppressor protein plays a major role in cellular response to DNA damage and other genomic aberrations. The activation of p53 can lead to either cell cycle arrest and DNA repair or apoptosis. p53 is phosphorylated at multiple sites in vivo and by several different protein kinases in vitro. p53 can apparently be phosphorylated by ATM, ATR, and DNA-PK at Ser15; the phosphorylation impairs the ability of MDM2 to bind p53, promoting both the accumulation and functional activation of p53 in response to DNA damage.

Immunogen Sequence:KLH-conjugated synthetic peptide encompassing a sequence within the N-term region of human p53.

Target Alternative Name:TP53 , p53 , LFS1 , TRP53 , P53 , tumor protein p53 , Li-Fraumeni syndrome

Species Reactivities:Human, Rat

Tag Line:/

Formulation:In 0.42% Potassium phosphate; 0.87% Sodium chloride; pH 7.3; 30% glycerol; and 0.01% sodium azide.

Purification: Affinity purified

Application:WB, IHC, IF

Positive Control:WB: Hela UV-treated; PC12 whole cell lysates; IHC: human breast cancer; IF: PC12 cells

Application And Usages:WB 1:500 – 1:1000; IHC 1:100 – 1:200; IF/IC 1:100 – 1:500; IP 1:10 – 1:100. However, the optimal conditions should be determined individually

Handling:The antibody solution should be gently mixed before use.

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Additional Information

Size:
100 µg
Antibody Target:
Phospho-p53
Category:
p53
Host:
Rabbit
Antibody Type:
Polyclonal
Isotype:
Rabbit IgG
Accession Number:
EAW90140
Gene Id:
7157
Concentration:
1 mg/ml
Appearance:
Colorless liquid
Form:
Liquid
Storage Condition:
-20 °C
Shipping Condition:
gel pack
Shelf Life:
12 months
Country of Animal Origin:
USA
Country of Manufacture:
USA
Usage:
For Research Use Only! Not to be used in humans.
Western Blot Verified:
Verified
Immunocytochemistry Verified:
Not Verified
Immunofluorescence Verified:
Verified
Immunoprecipitation Verified:
Not Verified
FACS Verified:
Not Verified
ELISA Verified:
Not Verified
ChIP Verified:
Not Verified
Dot Blot Verified:
Not Verified
Flow Cytometry Verified:
Not Verified
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