PARP Antibody (Clone 839120)

PARP Antibody (Clone 839120)is available at Gentaur for Next week Delivery.

Description: PARP, a 116 kDa nuclear poly (ADP-ribose) polymerase, appears to be involved in DNA repair in response to environmental stress. This protein can be cleaved by many ICE-like Caspases in vitro and is one of the main cleavage targets of caspase-3 in vivo. In human PARP, the cleavage occurs between Asp214 and Gly215, which separates the PARP amino-terminal DNA binding domain (24 kDa) from the carboxy-terminal catalytic domain (89 kDa). PARP helps cells to maintain their viability; cleavage of PARP facilitates cellular disassembly and serves as a marker of cells undergoing apoptosis.

Immunogen Sequence:E. coli-derived recombinant human PARP- Thr 373-Glu 540

Target Alternative Name:PARP1, ADPRT, PPOL, NAD (+) ADP-ribosyltransferase 1

Species Reactivities:Human

Tag Line:Monoclonal Antibody to detect PARP in human samples.

Formulation:100 µl of 0.5 mg/ml antibody in sterile PBS.

Purification: Protein A/G Purified Antibody

Application:Western Blot, IHC

Positive Control:Western Blot: HeLa cell lysate, IHC: human breast tissue.

Application And Usages:WB: 1 µg/ml, IHC: 8-25 µg/ml.

Handling:The antibody solution should be gently mixed before use.