PARP Antibody (Clone 2B6)

PARP Antibody (Clone 2B6)is available at Gentaur for Next week Delivery.

Description: PARP, a 116 kDa nuclear poly (ADP-ribose) polymerase, appears to be involved in DNA repair in response to environmental stress. This protein can be cleaved by many ICE-like Caspases in vitro and is one of the main cleavage targets of caspase-3 in vivo. In human PARP, the cleavage occurs between Asp214 and Gly215, which separates the PARP amino-terminal DNA binding domain (24 kDa) from the carboxy-terminal catalytic domain (89 kDa). PARP helps cells to maintain their viability; cleavage of PARP facilitates cellular disassembly and serves as a marker of cells undergoing apoptosis.

Immunogen Sequence:A synthetic peptide corresponding to residues before the cleavage site of human PARP-1 was used as immunogen. This antibody recognizes full-length form of PARP and PARP-1 only.

Target Alternative Name:PARP1, ADPRT, PPOL, NAD(+) ADP-ribosyltransferase 1

Species Reactivities:Human

Tag Line:Monoclonal antibody to detect PARP in human samples.

Formulation:Supplied in phosphate buffered saline (PBS), pH 7.2, containing 30% glycerol, 0.5% BSA

Purification: Protein G affinity chromatography

Application:WB

Positive Control:WB: Jurkat cells

Application And Usages:WB: 2-5 µg

Handling:The antibody solution should be gently mixed before use.