LC3B (Cleaved) Antibody

LC3B (Cleaved) Antibodyis available at Gentaur for Next week Delivery.

Description: Autophagy is an alternative process of proteasomal degradation for some long-lived proteins or organelles. Alterations in the autophagic-lysosomal compartment have been linked to neuronal death in many neurodegenerative disorders as well as in transmissible neuronal pathologies (prion diseases). Genetic studies in yeast have shown that Autophagy-defective Gene-8 (Atg-8) represents a specific marker for autophagy. Among the four families of mammalian Atg8-related proteins only LC3 (Microtubule-associated Protein1 Light Chain 3) is expressed at sufficient high levels and efficiently recruited to autophagic vesicles in cells and tissues. During autophagy the cytoplasmic form, LC3-I is processed and recruited to autophagosomes, where LC3-II is generated by site specific proteolysis near to the C-terminus. Autophagic vacuoles have been also reported frequently in cardiomyopathies or muscle cells exposed to different experimental settings.

Immunogen Sequence:This Cleaved LC3B antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 89-122 amino acids from human Cleaved LC3B.

Target Alternative Name:MAP1LC3B; MAP1ALC3; Microtubule-associated proteins 1A/1B light chain 3B; Autophagy-related protein LC3 B; Autophagy-related ubiquitin-like modifier LC3 B; MAP1 light chain 3-like protein 2; MAP1A/MAP1B light chain 3 B; Microtubule-associated protein 1 light chain 3 beta.

Species Reactivities:Human, Mouse. Predicted cross reactivity with bovine samples.

Tag Line:Polyclonal antibody to detect LC3B in human and mouse samples

Formulation:Supplied in PBS with 0.09% (W/V) sodium azide.

Purification: Affinity Purified Antibody

Application:Immunohistochemistry, IF

Positive Control:ICC: U251 cells, IF: SY5Y cells

Application And Usages:IF: 1:10-50, ICC: 1:10-50.

Handling:The antibody solution should be gently mixed before use.