LC3B (Cleaved) Antibody

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SKU:
6949-100
€285
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Description

LC3B (Cleaved) Antibodyis available at Gentaur for Next week Delivery.

Description: Autophagy is an alternative process of proteasomal degradation for some long-lived proteins or organelles. Alterations in the autophagic-lysosomal compartment have been linked to neuronal death in many neurodegenerative disorders as well as in transmissible neuronal pathologies (prion diseases). Genetic studies in yeast have shown that Autophagy-defective Gene-8 (Atg-8) represents a specific marker for autophagy. Among the four families of mammalian Atg8-related proteins only LC3 (Microtubule-associated Protein1 Light Chain 3) is expressed at sufficient high levels and efficiently recruited to autophagic vesicles in cells and tissues. During autophagy the cytoplasmic form, LC3-I is processed and recruited to autophagosomes, where LC3-II is generated by site specific proteolysis near to the C-terminus. Autophagic vacuoles have been also reported frequently in cardiomyopathies or muscle cells exposed to different experimental settings.

Immunogen Sequence:This Cleaved LC3B antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 89-122 amino acids from human Cleaved LC3B.

Target Alternative Name:MAP1LC3B; MAP1ALC3; Microtubule-associated proteins 1A/1B light chain 3B; Autophagy-related protein LC3 B; Autophagy-related ubiquitin-like modifier LC3 B; MAP1 light chain 3-like protein 2; MAP1A/MAP1B light chain 3 B; Microtubule-associated protein 1 light chain 3 beta.

Species Reactivities:Human, Mouse. Predicted cross reactivity with bovine samples.

Tag Line:Polyclonal antibody to detect LC3B in human and mouse samples

Formulation:Supplied in PBS with 0.09% (W/V) sodium azide.

Purification: Affinity Purified Antibody

Application:Immunohistochemistry, IF

Positive Control:ICC: U251 cells, IF: SY5Y cells

Application And Usages:IF: 1:10-50, ICC: 1:10-50.

Handling:The antibody solution should be gently mixed before use.

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Additional Information

Size:
100 µl
Antibody Target:
LC3
Category:
LC3
Lot Number:
10B126949
Host:
Rabbit
Antibody Type:
Polyclonal
Isotype:
Rabbit Ig
Accession Number:
Q9GZQ8
Gene Id:
81631
Concentration:
N/A
Appearance:
Colorless liquid
Form:
Liquid
Storage Condition:
-20 °C
Shipping Condition:
gel pack
Shelf Life:
12 months
Country of Animal Origin:
USA
Country of Manufacture:
USA
Usage:
For Research Use Only! Not to be used in humans.
Western Blot Verified:
Not Verified
Immunocytochemistry Verified:
Not Verified
Immunofluorescence Verified:
Verified
Immunoprecipitation Verified:
Not Verified
ELISA Verified:
Not Verified
ChIP Verified:
Not Verified
Dot Blot Verified:
Not Verified
Flow Cytometry Verified:
Not Verified
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