LAMP-2 Antibody (CT)

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SKU:
5078-100
€325
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Description

LAMP-2 Antibody (CT)is available at Gentaur for Next week Delivery.

Description: Autophagy, the process of bulk degradation of cellular proteins throμgh an autophagosomic-lysosomal pathway is important for normal growth control and may be defective in tumor cells. It is involved in the preservation of cellular nutrients under starvation conditions as well as the normal turnover of cytosolic components and is negatively regulated by TOR (Target of rapamycin). LAMP-2, a highly glycosylated protein associated with the lysosome, has recently been shown to be important in autophagy as mice deficient in this protein failed to convert autophagic vacuoles into vacuoles leading to impaired degradation of long-lived proteins. This correlates with the finding that human LAMP-2 deficiency causing Danon's disease is associated with the accumulation of autophagic material in striated myocytes. LAMP-2 exists in multiple isoforms.

Immunogen Sequence:LAMP-2 antibody was raised against a 17 amino acid peptide from near the carboxy terminus of human LAMP-2.

Target Alternative Name:LAMP-2, Lysosome associated membrane protein 2

Species Reactivities:Human, mouse

Tag Line:/

Formulation:100 µg (1 mg/ml) in 1X PBS containing 0.02% sodium azide.

Purification: Affinity chromatography purified via peptide column.

Application:Western blot, Immunocytochemistry, ELISA

Positive Control:Western Blot: HepG2 cell lysate Immunocytochemistry: HepG2 cells

Application And Usages:Western Blot: 1 - 2 μg/ml, Immunocytochemistry: 10 μg/ml, ELISA. However, the optimal conditions should be determined individually.

Handling:The antibody solution should be gently mixed before use.

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Additional Information

Size:
100 µg
Antibody Target:
LAMP-2
Category:
LAMP
Lot Number:
70678
Host:
Rabbit
Antibody Type:
Polyclonal
Isotype:
Rabbit IgG1
Accession Number:
P13473
Gene Id:
3920
Concentration:
1 mg/ml
Appearance:
Colorless liquid
Form:
Liquid
Storage Condition:
-20 °C
Shipping Condition:
gel pack
Shelf Life:
12 months
Country of Animal Origin:
China
Country of Manufacture:
USA
Usage:
For Research Use Only! Not to be used in humans.
Western Blot Verified:
Verified
Immunocytochemistry Verified:
Not Verified
Immunofluorescence Verified:
Not Verified
Immunoprecipitation Verified:
Not Verified
FACS Verified:
Not Verified
ELISA Verified:
Verified
ChIP Verified:
Not Verified
Flow Cytometry Verified:
Not Verified
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