DRAM Antibody (NT)

DRAM Antibody (NT)is available at Gentaur for Next week Delivery.

Description: Damage-regulated autophagy modulator (DRAM) is a p53 target gene encoding a lysosomal protein that induces autophagy, a process that degrades cytosolic proteins and organelles. It has been sμggested that activation of DRAM by p53 is simultaneous to the activation by p53 of one or more proapoptotic genes such as PUMA, Bax, etc., and that the signaling pathways regulated by these genes promote a full cell death response. By itself, DRAM cannot induce apoptosis, but the fact that it is inactivated in certain cancers highlights the importance of DRAM and sμggests that autophagy may play a more important role in cancer than initially suspected. At least two different isoforms of DRAM are known to exist.

Immunogen Sequence:DRAM antibody was raised against a 16 amino acid peptide from near the amino terminus of human DRAM.

Target Alternative Name:Damage-regulated autophagy modulator

Species Reactivities:Human, mouse, rat

Tag Line:/

Formulation:100 µg (1 mg/ml) in 1X PBS containing 0.02% sodium azide.

Purification: Affinity chromatography purified via peptide column.

Application:Western blot, Immunohistochemistry, ELISA

Positive Control:Western Blot: K562 cell lysate Immunohistochemistry: Human liver tissue

Application And Usages:Western Blot: 0.5-2 μg/ml, Immunohistochemistry: 2.5 μg/ml, ELISA. However, the optimal conditions should be determined individually.

Handling:The antibody solution should be gently mixed before use.